Gyne-Lotrimin cream (Clotrimazole)

Gyne-Lotrimin cream
4.56 ratingsReviews
Generic:
Clotrimazole
Indications:
infections
Analogs:
Clotrimazole Canesten Miconazole Monistat Tioconazole Vagistat 1 Terconazole Terazol Butoconazole Gynazole 1 Fluconazole Diflucan Nystatin Mycelex

UK equivalent: Canesten

In the UK, a close equivalent to Gyne-Lotrimin is Canesten, as both contain clotrimazole for treating vaginal thrush. Brand names vary by country, but the active ingredient and purpose are the same. Canesten pessary and Canesten Duo will be added to our catalogue soon.
In stock: 14 packs
AdultsPregnancyAllergiesDiabetesBreastfeedingChildrenDriving

Dosages

Gyne-Lotrimin cream 100 mg

Quantity Price per tablet You save Total price
10 £2.44 - £24.45
20 £1.56 £17.78 £31.11
30 £1.26 £35.56 £37.78

Manufacturers

Bayer Australia LtdBayer HealthCare LLCBayer Hispania S.L.Bayer Inc.Bayer plcBayer S.p.A.Bayer Vital GmbHGlenmark Pharmaceuticals Ltd.Taro Pharmaceuticals Inc.

Payment & Delivery

Package Example

Your order is carefully packed and is dispatched within 24 hours. Here is what a typical package looks like.

Sized like a regular personal letter (approximately 24x11x0.7 cm), with no indication of what is inside.

Front View
Front View
Side View
Side View
Back View
Back View
Delivery Times
Delivery MethodEstimated delivery
Express Free for orders over £222.24Estimated delivery to the UK: 4-7 days
Standard Free for orders over £148.16Estimated delivery to the UK: 14-21 days
EMSRoyal Mail
Payment Methods
VisaMastercardAmerican ExpressJCBBitcoin, USDTApple PayGoogle PayPayPalKlarnaClearpay

Discount Coupons

  • New Year's Day - 1 January 2026 9% NEWYEAR9
  • Valentine's Day - 14 February 2026 6% VALENTINE6
  • St David's Day - 1 March 2026 4% DAVID4
  • St Patrick's Day - 17 March 2026 5% PATRICK5
  • St George's Day - 23 April 2026 4% GEORGE4
  • May Day - 1 May 2026 5% MAYDAY5
  • Halloween - 31 October 2026 6% HALLOWEEN6
  • Guy Fawkes Night - 5 November 2026 5% GUY5
  • Christmas Eve - 24 December 2026 9% XMASEVE9
  • Christmas Day - 25 December 2026 10% XMAS10
  • Boxing Day - 26 December 2026 10% BOXING10
  • New Year's Eve - 31 December 2026 8% NYE8

Brand Names

Also known as (by country):
CountryBrand Names
United Kingdom
Canesten

FAQ

Do not save leftover clotrimazole vaginal cream for a future episode or share it with anyone else. Keep it in the original tube until it can be taken to a pharmacy for advice on safe disposal, and do not flush it down the toilet or sink.

UK authorisation cannot be confirmed for the exact supplied product from the available product details. The name, formulation and marketing authorisation holder on the received package would need to be checked before making a product-specific authorisation claim.

Do not use the vaginal cream if a seal is broken, the tube is punctured or leaking, or the packaging is otherwise damaged. Keep the product and packaging so that the active ingredient, strength, batch number and expiry date can be checked before use.

Clotrimazole 1% vaginal cream is an azole antifungal used to treat vaginal thrush, also called vulvovaginal candidiasis, caused by Candida yeast. It is not suitable for every cause of vaginal itching, discharge or discomfort.

During pregnancy, use clotrimazole vaginal cream only under medical supervision; an applicator should not be used during pregnancy. It may be used while breastfeeding because absorption after vaginal use is minimal.

Description

Note: Images in the description are provided for informational purposes and may differ from the actual appearance of the product. Please refer to the product name, strength, active ingredients, and pharmaceutical form.

Clotrimazole Vaginal Cream is an antifungal medicine primarily used to treat vaginal yeast infections caused by Candida species. It works by inhibiting the growth of fungi, thereby alleviating symptoms such as itching, burning, and discharge associated with these infections.

Clotrimazole Vaginal Cream (Gyne-Lotrimin)

What Is Clotrimazole Vaginal Cream?

Clotrimazole is an azole antifungal effective against various fungal infections, particularly vulvovaginal candidiasis. It is available in cream form for intravaginal use, typically administered at bedtime for a specified duration, depending on the concentration.

A yeast infection is a common type of vaginal infection. Your doctor may call it candidiasis. This condition is caused by an organism called Candida, a yeast type. Healthy women usually have this yeast on the skin, in the mouth, in the digestive tract, and in the vagina. At times, the yeast can increase. The infection is sometimes called yeast (Candida) "overgrowth." Some women may have a yeast infection on the skin outside the vagina (vulva) associated with the vaginal infection.

A yeast infection can occur at any age. It is most common during the childbearing years. Women who are pregnant or diabetic, taking antibiotics, birth control pills, or steroids, or who have a weakened immune system are more likely to get repeated yeast infections.

Symptoms of a Vaginal Yeast Infection

  • vaginal itching (ranging from mild to severe);
  • a clumpy vaginal discharge that may look like cottage cheese;
  • vaginal soreness, irritation, or burning;
  • rash or redness on the skin outside the vagina (vulvar irritation).

Forms and Dosage of Clotrimazole

Formulation

Dosage

Administration

Clotrimazole 1%

1 applicatorful

Intravaginally one applicatorful daily (50 mg) at bedtime for 7 consecutive days.

Clotrimazole 2%

1 applicatorful

Intravaginally one applicatorful daily (100 mg) at bedtime for 3 consecutive days.

How to Use Clotrimazole for Vaginal Application

  • Wash your hands before use.
  • Use the provided applicator to insert the cream as high as possible into the vagina, preferably at bedtime.
  • Avoid using tampons, douches, spermicides, or other vaginal products during treatment.
  • To reduce irritation and improve effectiveness, consider avoiding sexual intercourse during treatment.

What Do I Do if I Miss a Dose?

If you forgot your dose, use it as soon as you remember. If it is close to your next dose, skip the missed dose and return to your schedule. Do not use two doses at the same time.

Clotrimazole Vaginal Cream (Gyne-Lotrimin)

Prescription

Clotrimazole Vaginal Cream is available over the counter (OTC) in many regions, meaning a prescription is not typically required for purchase. However, it is advisable to consult a healthcare professional if this is the first occurrence of symptoms or if symptoms persist.

Clinical Pharmacology

Mechanism of Action

Clotrimazole inhibits the biosynthesis of ergosterol, a crucial component of the fungal cell membrane, disrupting membrane function and inhibiting fungal growth.

Pharmacokinetics

When administered vaginally, only a small proportion is absorbed systemically (about 5% to 10%). Therapeutic concentrations can persist locally for up to several days after application.

Important Safety Information

Possible side effects include vaginal burning, irritation, and abdominal cramps. Seek medical attention if severe allergic reactions occur or symptoms do not improve after treatment.

Latex contraception notice: clotrimazole cream can damage latex (e.g., condoms or diaphragms) and may reduce their effectiveness. Use alternative contraception during treatment and for a short period after the last dose (follow the product label/leaflet for the exact duration).

If swallowed, call a doctor or poisons information centre right away.

Contraindications to Clotrimazole

  1. Allergy to clotrimazole or any component of the product.
  2. Unverified vaginal infection: do not self-treat if you have never had a doctor-confirmed yeast infection.
  3. Eye contact: avoid contact with eyes due to risk of severe irritation.
  4. Pregnancy and breastfeeding: use only when needed and discuss risks/benefits with a healthcare professional.

Side Effects

  • Local irritation (burning, redness, swelling).
  • Abdominal discomfort.
  • Allergic reactions (rash, hives, swelling, breathing difficulty) - seek urgent help.

Interactions of Clotrimazole Cream with Other Medicines

Due to minimal systemic absorption, clinically significant interactions are uncommon. However, caution may be needed with some medicines in specific clinical situations.

Storage

Store at room temperature, ideally 20°C to 25°C (68°F to 77°F) (acceptable range 15°C to 30°C (59°F to 86°F)). Keep tightly closed, away from moisture and direct sunlight, and out of reach of children.

Medically reviewed by
Donna Brettler
BPharm, MPH - Pharmacologist and medical writer
Updated 6 August 2026

Customer questions

Asked by Hannah, Coventry, United Kingdom

Before I order, can you confirm that the cream will have a reasonable amount of shelf life remaining when it arrives?

Answered by Support team

We cannot guarantee a minimum remaining shelf life in advance. Check the expiry date printed on the tube or outer packaging when it arrives, and store the cream at 20°C to 25°C with the tube tightly closed; do not refrigerate.

Asked by Margaret, Sheffield, United Kingdom

I am 63 and have developed what I think is thrush for the first time. Can I treat it myself with this vaginal cream?

Answered by Support team
Medical reviewed by Brian Holtry

This vaginal cream is not recommended for self-treatment over age 60 unless a doctor advises it. First-time vaginal symptoms at this age should be assessed, as they can have causes other than thrush.

Product specifications

Active ingredientClotrimazole
Drug classAzole antifungal
Dosage formVaginal cream
Available strengths1%
RouteVaginal
StorageStore at 20°C to 25°C and keep the tube tightly closed; do not refrigerate.
ATC codeG01AF02

Regulatory information

United Kingdom: medicine status
Registration statusThe supplied Gyne-Lotrimin cream name and 100 mg presentation cannot be confirmed as a UK-authorised medicinal product from the available information; UK authorisation must be verified for the exact name, formulation and marketing authorisation holder.
UK supply categoryThe prescription classification for this exact product is unknown because it has not been identified as a UK-authorised presentation; clotrimazole supply categories vary by formulation and product.
Official medicine informationThe NHS provides patient information on clotrimazole, including its use for fungal infections and available formulations.Safety monitoringSuspected side effects from medicines can be reported to the MHRA through the Yellow Card Scheme.

More information