Roxithromycin

Roxithromycin
Indications:
infections

Dosages

Roxithromycin 150 mg

Quantity Price per tablet Total price
60 £0.73 £43.71
90 £0.67 £60.00
120 £0.63 £75.56
180 £0.60 £108.16
270 £0.58 £156.31
360 £0.57 £205.94

Payment & Delivery

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Delivery Times
Delivery MethodEstimated delivery
Express Free for orders over £222.24Estimated delivery to the UK: 4-7 days
Standard Free for orders over £148.16Estimated delivery to the UK: 14-21 days
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Brand Names

Also known as (by country):
CountryBrand Names
Argentina
Anuar Delos Klomicina Rulid Sinurit
Australia
Biaxin Biaxsig Roxar Roximycin Rulide
Belgium
Claramid Docroxithro Rulid
Brazil
Floxid Rotram Roxid Roxina Roxitran Roxitricina Roxitrom Roxitromin Rulid
Czechia
Rovenal Rulid
Denmark
Forilin Forimycin Roximstad Surlid
Finland
Roxibion Surlid
France
Claramid Rulid Subroxine
Germany
Infectoroxit Romyk Roxi Roxi-paed Roxi-Puren Roxi-Q Roxi-saar Roxibeta Roxidura Roxigamma Roxigrun RoxiHefa RoxiHexal Roxiklinge Roxithro-Lich Rulid
Greece
Acevor Anti-Bio Aristomycin Asmetic Azuril Bazuctril Bicofen Delitroxin Erybros Hobatmycine Macrolid-S Neo-Suxigal Nirox Oxetine Redotrin Roxibron Roxicillin Roximin Roxitazon Roxivinol Roxy-Due Roxyspes Rulid Seide Siguon Thriostaxil Tirabicin Toscamycin-R Uramilon Vaselpin Vomitoran
Hungary
Renicin Rulid
Italy
Assoral Overal Rossitrol Rulid
Malaysia
Roxcin Roxinox Rulid Uonin
Mexico
Crolix Kensodic Roxitrol Rulid Sertrom Surlid
Netherlands
Rulide
New Zealand
Romicin Rulide
Poland
Renicin Rolicyn Roxiratio Roxitron Rulid Xitrocin
Portugal
Inferoxin Odonticina Roxitron Rulide
Spain
Macrosil Rotesan Rotramin Rulide
Sweden
Cirumycin Surlid
Turkey
Remora Ritosin Roksimin Roksolit Rulid

Description

Note: Images in the description are provided for informational purposes and may differ from the actual appearance of the product. Please refer to the product name, strength, active ingredients, and pharmaceutical form.

Roxithromycin is a macrolide antibiotic used in some countries to treat susceptible bacterial infections, most commonly respiratory tract infections and some skin and soft tissue infections. It is a prescription-only medicine taken by mouth; in the UK, prescribing and availability depend on local clinical practice and specialist guidance.

Roxithromycin

What it is used for

In the UK, roxithromycin may be prescribed for bacterial infections caused by susceptible organisms, including some upper and lower respiratory tract infections and some skin and soft tissue infections. It does not work against viral illnesses such as colds or flu.

How to take

In markets where it is approved, roxithromycin is typically taken by mouth once or twice daily, often at least 15 minutes before meals, as food can reduce absorption. Follow your prescriber's instructions and complete the full course unless you are told otherwise.

Roxithromycin vs other antibiotics

Comparison Roxithromycin Amoxicillin Azithromycin Erythromycin
Drug class Macrolide Penicillin (beta-lactam) Macrolide (azalide) Macrolide
Typical role An alternative in some countries for susceptible respiratory and skin infections A common first-line option for many ENT and respiratory infections, when appropriate Often used for certain respiratory infections and some atypical pathogens, when appropriate An older macrolide; still used, but often limited by GI side effects and interactions
Penicillin allergy May be an alternative for some people with penicillin allergy, depending on clinical judgement Not suitable in true immediate-type penicillin allergy May be an alternative for some people with penicillin allergy, depending on clinical judgement May be an alternative for some people with penicillin allergy, depending on clinical judgement
Food effect Absorption can be reduced by food, so it is often taken before meals It can usually be taken with or without food, depending on the product Depends on the formulation; many can be taken with or without food Depends on the salt or formulation; some are affected by food
Common side effects GI upset (nausea, abdominal pain, diarrhoea), headache, rash GI upset, rash; diarrhoea can occur GI upset; diarrhoea; often less nausea than erythromycin GI upset is common; nausea and abdominal cramps are frequent
QT/arrhythmia risk Macrolide class warning: QT prolongation can occur in rare cases Not a typical QT-prolonging antibiotic Macrolide class warning: QT prolongation can occur in rare cases Macrolide class warning: QT prolongation can occur in rare cases
Drug interaction potential Can interact with some medicines (see below); use caution with anticoagulants Fewer CYP-related interactions than macrolides Generally fewer CYP3A interactions than erythromycin or clarithromycin More CYP-related interactions than many alternatives

When doctors usually choose which

Scenario (simplified) Often considered Notes
A typical bacterial ENT or respiratory infection where a beta-lactam is appropriate Amoxicillin A common first-line choice in many guidelines and markets; this depends on the diagnosis and local resistance patterns.
Suspected "atypical" respiratory pathogens, or when a macrolide-type option is needed Azithromycin Often preferred within the macrolide class because of convenient dosing and generally fewer CYP3A interactions than erythromycin.
Need for a macrolide alternative where it is available locally Roxithromycin Used in some countries; local product information should be taken into account.
A macrolide is needed but newer alternatives are not suitable or not available Erythromycin It can be effective in some settings, but GI side effects and interactions can limit its use.
When to be extra cautious with macrolides Roxithromycin / Azithromycin / Erythromycin Use caution with known QT prolongation, electrolyte abnormalities, or other QT-prolonging medicines.

How it works

Roxithromycin is a macrolide antibiotic. It binds to the 50S ribosomal subunit and inhibits bacterial protein synthesis.

Side effects

Common side effects include nausea, abdominal pain, diarrhoea, headache and skin rash.

Stop taking the medicine and get urgent medical help if you develop signs of a serious allergic reaction, such as swelling of the face, lips or tongue, difficulty breathing, severe skin reactions with blistering or peeling, severe or persistent diarrhoea, or symptoms of liver injury such as dark urine, yellowing of the skin or eyes, or severe tiredness.

Warnings and precautions

  • Heart rhythm: rare cases of QT prolongation and serious arrhythmias have been reported with macrolides. Use extra caution if you have known QT prolongation, low potassium or magnesium, a slow heart rate, or if you take other QT-prolonging medicines.
  • Antibiotic-associated diarrhoea: severe diarrhoea, including C. difficile colitis, can occur during or after antibiotic treatment.
  • Liver: liver injury has been reported rarely. Use caution in severe hepatic impairment and follow your clinician's advice.
  • Kidney: rare cases of interstitial nephritis have been reported.

Drug-drug interactions

Tell your clinician or pharmacist about all the medicines and supplements you take. Important interactions may include:

  • Warfarin and other vitamin K antagonists: increased INR and bleeding have been reported; INR monitoring is recommended during combined use.
  • Statins and fibrates: rare cases of muscle toxicity have been reported with interacting combinations; report muscle pain or weakness promptly.
  • Theophylline: levels may increase slightly; monitoring may be needed in some people.
  • QT-prolonging medicines: taking these together can increase the risk of arrhythmias.

Special populations

  • Pregnancy and breastfeeding: use only if prescribed. Small amounts may pass into breast milk; discuss the risks and benefits with a clinician.
  • Hepatic impairment: dose reduction may be recommended in severe hepatic impairment, under clinician guidance.
  • Renal impairment: for short courses, dose adjustment is often not required; severe impairment should be managed by a clinician.
  • Children: paediatric dosing is weight-based and should follow local product information and clinician guidance.

Pharmacokinetics

Roxithromycin has an absolute bioavailability of approximately 50%. Peak concentrations typically occur about 1-2 hours after dosing. Food can reduce absorption. It is highly protein-bound and distributes into tissues; small amounts may be found in breast milk. It is eliminated through several routes, including faecal and urinary excretion, with a reported half-life of around 12 hours in healthy adults. The half-life may be prolonged in hepatic or renal impairment.

Off-label / investigational mentions

Some studies have looked at macrolides, including roxithromycin, for conditions such as gingival overgrowth or cardiovascular prevention. These are not standard labelled indications.

Storage

Store below 25°C (77°F) in a cool, dry place. Protect from light and moisture. Keep out of the sight and reach of children.

Reviewed by
Donna Brettler
BPharm, MPH - Pharmacologist and medical writer

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