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Roxithromycin
Generic:
Roxithromycin
Indications:
infections
Analogs:
Azithromycin Clarithromycin Erythromycin Spiramycin Josamycin Amoxicillin Doxycycline Rulide Augmentin Levofloxacin
In stock: 19 packs
AdultsPregnancyAllergiesDiabetesBreastfeedingChildrenDriving
Dosages
Roxithromycin 150 mg
| Quantity | Price per tablet | You save | Total price | |
|---|---|---|---|---|
| 60 | £1.06 | - | £63.71 | |
| 90 | £0.97 | £8.15 | £87.41 | |
| 120 | £0.92 | £17.04 | £110.38 | |
| 180 | £0.88 | £33.34 | £157.79 | |
| 270 | £0.84 | £59.26 | £227.43 | |
| 360 | £0.83 | £82.97 | £299.28 |
This tool only estimates pack size from the values you enter.
You need: 21 tabsRecommended packs: 1 x 60 = 60 tabs
Manufacturers
Alphapharm Pty LtdMerckle GmbHSanofi-Aventis AustraliaSanofi-Aventis Deutschland GmbHSanofi-Aventis, S.A.Sanofi S.p.A.Sanofi Winthrop Industrie
Payment & Delivery
Package Example
Your order is carefully packed and is dispatched within 24 hours. Here is what a typical package looks like.
Sized like a regular personal letter (approximately 24x11x0.7 cm), with no indication of what is inside.
Delivery Times
| Delivery Method | Estimated delivery |
|---|---|
| Express Free for orders over £222.24 | Estimated delivery to the UK: 4-7 days |
| Standard Free for orders over £148.16 | Estimated delivery to the UK: 14-21 days |
Payment Methods
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FAQ
If symptoms do not start to improve as expected, or worsen at any point, arrange a clinical reassessment. Do not increase the dose, extend the course or add another antibiotic without medical advice, as the infection may need a different treatment or further investigation.
The supplied product details do not confirm a UK marketing authorisation for the particular product that would be supplied. Roxithromycin is not authorised as a marketed human medicine in the United Kingdom, so the product's manufacturer, packaging and regulatory status should not be assumed from its name alone.
Do not take the tablets until the discrepancy has been checked. Compare the package label for the active ingredient, dosage form and strength; this product is listed as Roxithromycin 150 mg film-coated tablets. Keep the package, including the batch number and expiry date, and ask us to investigate the order.
Roxithromycin is a macrolide antibiotic used to treat susceptible bacterial infections, including some respiratory tract, urinary tract and skin or soft-tissue infections. It does not treat viral illnesses such as colds or flu, and the appropriate antibiotic depends on the infection and likely bacteria.
Description
Note:
Images in the description are provided for informational purposes and may differ from the actual appearance of the product. Please refer to the product name, strength, active ingredients, and pharmaceutical form.
Roxithromycin is a macrolide antibiotic used in some countries to treat susceptible bacterial infections, most commonly respiratory tract infections and some skin and soft tissue infections. It is a prescription-only medicine taken by mouth; in the UK, prescribing and availability depend on local clinical practice and specialist guidance.
UK note: Roxithromycin is not authorised by the MHRA in the United Kingdom. Any use in the UK should be guided by a registered prescriber.
What it is used for
In the UK, roxithromycin may be prescribed for bacterial infections caused by susceptible organisms, including some upper and lower respiratory tract infections and some skin and soft tissue infections. It does not work against viral illnesses such as colds or flu.
How to take
In markets where it is approved, roxithromycin is typically taken by mouth once or twice daily, often at least 15 minutes before meals, as food can reduce absorption. Follow your prescriber's instructions and complete the full course unless you are told otherwise.
Roxithromycin vs other antibiotics
| Comparison | Roxithromycin | Amoxicillin | Azithromycin | Erythromycin |
|---|---|---|---|---|
| Drug class | Macrolide | Penicillin (beta-lactam) | Macrolide (azalide) | Macrolide |
| Typical role | An alternative in some countries for susceptible respiratory and skin infections | A common first-line option for many ENT and respiratory infections, when appropriate | Often used for certain respiratory infections and some atypical pathogens, when appropriate | An older macrolide; still used, but often limited by GI side effects and interactions |
| Penicillin allergy | May be an alternative for some people with penicillin allergy, depending on clinical judgement | Not suitable in true immediate-type penicillin allergy | May be an alternative for some people with penicillin allergy, depending on clinical judgement | May be an alternative for some people with penicillin allergy, depending on clinical judgement |
| Food effect | Absorption can be reduced by food, so it is often taken before meals | It can usually be taken with or without food, depending on the product | Depends on the formulation; many can be taken with or without food | Depends on the salt or formulation; some are affected by food |
| Common side effects | GI upset (nausea, abdominal pain, diarrhoea), headache, rash | GI upset, rash; diarrhoea can occur | GI upset; diarrhoea; often less nausea than erythromycin | GI upset is common; nausea and abdominal cramps are frequent |
| QT/arrhythmia risk | Macrolide class warning: QT prolongation can occur in rare cases | Not a typical QT-prolonging antibiotic | Macrolide class warning: QT prolongation can occur in rare cases | Macrolide class warning: QT prolongation can occur in rare cases |
| Drug interaction potential | Can interact with some medicines (see below); use caution with anticoagulants | Fewer CYP-related interactions than macrolides | Generally fewer CYP3A interactions than erythromycin or clarithromycin | More CYP-related interactions than many alternatives |
When doctors usually choose which
| Scenario (simplified) | Often considered | Notes |
|---|---|---|
| A typical bacterial ENT or respiratory infection where a beta-lactam is appropriate | Amoxicillin | A common first-line choice in many guidelines and markets; this depends on the diagnosis and local resistance patterns. |
| Suspected "atypical" respiratory pathogens, or when a macrolide-type option is needed | Azithromycin | Often preferred within the macrolide class because of convenient dosing and generally fewer CYP3A interactions than erythromycin. |
| Need for a macrolide alternative where it is available locally | Roxithromycin | Used in some countries; local product information should be taken into account. |
| A macrolide is needed but newer alternatives are not suitable or not available | Erythromycin | It can be effective in some settings, but GI side effects and interactions can limit its use. |
| When to be extra cautious with macrolides | Roxithromycin / Azithromycin / Erythromycin | Use caution with known QT prolongation, electrolyte abnormalities, or other QT-prolonging medicines. |
How it works
Roxithromycin is a macrolide antibiotic. It binds to the 50S ribosomal subunit and inhibits bacterial protein synthesis.
Side effects
Common side effects include nausea, abdominal pain, diarrhoea, headache and skin rash.
Stop taking the medicine and get urgent medical help if you develop signs of a serious allergic reaction, such as swelling of the face, lips or tongue, difficulty breathing, severe skin reactions with blistering or peeling, severe or persistent diarrhoea, or symptoms of liver injury such as dark urine, yellowing of the skin or eyes, or severe tiredness.
Warnings and precautions
- Heart rhythm: rare cases of QT prolongation and serious arrhythmias have been reported with macrolides. Use extra caution if you have known QT prolongation, low potassium or magnesium, a slow heart rate, or if you take other QT-prolonging medicines.
- Antibiotic-associated diarrhoea: severe diarrhoea, including C. difficile colitis, can occur during or after antibiotic treatment.
- Liver: liver injury has been reported rarely. Use caution in severe hepatic impairment and follow your clinician's advice.
- Kidney: rare cases of interstitial nephritis have been reported.
Drug-drug interactions
Tell your clinician or pharmacist about all the medicines and supplements you take. Important interactions may include:
- Warfarin and other vitamin K antagonists: increased INR and bleeding have been reported; INR monitoring is recommended during combined use.
- Statins and fibrates: rare cases of muscle toxicity have been reported with interacting combinations; report muscle pain or weakness promptly.
- Theophylline: levels may increase slightly; monitoring may be needed in some people.
- QT-prolonging medicines: taking these together can increase the risk of arrhythmias.
Special populations
- Pregnancy and breastfeeding: use only if prescribed. Small amounts may pass into breast milk; discuss the risks and benefits with a clinician.
- Hepatic impairment: dose reduction may be recommended in severe hepatic impairment, under clinician guidance.
- Renal impairment: for short courses, dose adjustment is often not required; severe impairment should be managed by a clinician.
- Children: paediatric dosing is weight-based and should follow local product information and clinician guidance.
Pharmacokinetics
Roxithromycin has an absolute bioavailability of approximately 50%. Peak concentrations typically occur about 1-2 hours after dosing. Food can reduce absorption. It is highly protein-bound and distributes into tissues; small amounts may be found in breast milk. It is eliminated through several routes, including faecal and urinary excretion, with a reported half-life of around 12 hours in healthy adults. The half-life may be prolonged in hepatic or renal impairment.
Off-label / investigational mentions
Some studies have looked at macrolides, including roxithromycin, for conditions such as gingival overgrowth or cardiovascular prevention. These are not standard labelled indications.
Storage
Store below 25°C (77°F) in a cool, dry place. Protect from light and moisture. Keep out of the sight and reach of children.
BPharm, MPH - Pharmacologist and medical writer
Customer questions
I developed hives after clarithromycin a few years ago. Is it safe for me to take Roxithromycin 150 mg tablets?
Do not start Roxithromycin until a clinician or pharmacist has assessed that reaction. Roxithromycin is a macrolide antibiotic, and a previous allergy to clarithromycin, erythromycin or another macrolide may indicate a risk of cross-reactivity.
Product specifications
| Active ingredient | Roxithromycin |
|---|---|
| Drug class | Macrolide antibiotic |
| Dosage form | Film-coated tablet |
| Available strengths | 150 mg |
| Route of administration | Oral |
| Storage | Store below 25°C in a dry place, protected from moisture and light. |
| ATC code | J01FA06 |
Regulatory information
Licensing statusIn the United Kingdom, roxithromycin is not authorised for human medical use.
More information
Reviews
This product has 4 ratings, but only 3 written reviews so far. Share your experience and help other customers.
HM
Holly M, Birmingham
Verified review
The parcel arrived in neutral packaging, with discreet labelling that did not advertise what was inside.
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AK
Alexander K, Plymouth
Verified review
Everything was packed properly.
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HC
Hannah C, Leeds
Verified review
I was pleased when it arrived.
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