Mebendazole

Mebendazole is a synthetic anthelmintic medicine that is structurally related to albendazole and thiabendazole.

Uses

Its broad spectrum of activity makes it useful for treating mixed helminth infections. Mebendazole has produced egg reduction rates and/or cure rates of over 90% in patients with enterobiasis, ascariasis, or hookworm infection caused by A. duodenale or N. americanus, and has produced egg reduction rates of over 90% and cure rates of around 70% in patients with trichuriasis.

The effectiveness of mebendazole in treating helminth infections varies depending on factors such as pre-existing diarrhoea, GI transit time, the degree of infection, and the helminth strain. Cure rates are usually lower than average in patients with heavy infections and in those with GI hypermotility.

Although other anthelmintics (for example, praziquantel and albendazole) are usually recommended for infections caused by cestodes (tapeworms), mebendazole has been used to treat intestinal infections caused by the adult forms of certain tapeworms, including Hymenolepis nana (dwarf tapeworm), Taenia saginata (beef tapeworm), and T. solium (pork tapeworm), as well as hydatid disease caused by the larval form of Echinococcus granulosus (dog tapeworm).

Nematode (Roundworm) Infections

Ascariasis

Mebendazole is used to treat ascariasis caused by Ascaris lumbricoides. Albendazole, mebendazole, or pyrantel pamoate are considered the drugs of choice for treating ascariasis.

Enterobiasis

Mebendazole is used to treat enterobiasis caused by Enterobius vermicularis (pinworm). Albendazole, mebendazole, or pyrantel pamoate are considered the drugs of choice for treating enterobiasis.

Filariasis

Mebendazole or albendazole are considered the drugs of choice for treating filariasis caused by Mansonella perstans. Mebendazole has also been used to treat onchocerciasis (filariasis caused by Onchocerca volvulus), but ivermectin is usually considered the drug of choice for this infection. Other anthelmintics, usually diethylcarbamazine where available through specialist infectious disease or tropical medicine services, are recommended for infections caused by most other filarial worms.

Hookworm Infections

Mebendazole is used to treat intestinal hookworm infections caused by Ancylostoma duodenale or Necator americanus in single or mixed infections. Albendazole, mebendazole, or pyrantel pamoate are considered the drugs of choice for intestinal hookworm infections. Mebendazole has also been used to treat cutaneous larva migrans (creeping eruption) caused by dog and cat hookworms. However, cutaneous larva migrans usually gets better on its own after several weeks or months, and other medicines (albendazole, ivermectin, thiabendazole) are usually recommended if treatment is needed. Mebendazole, albendazole, or pyrantel pamoate are considered drugs of choice for treating eosinophilic enterocolitis caused by Ancylostoma caninum (dog hookworm).

Toxocariasis (Visceral Larva Migrans)

Mebendazole is used to treat toxocariasis (visceral larva migrans) caused by Toxocara canis or T. cati (dog and cat roundworms), and albendazole or mebendazole are considered the drugs of choice for these infections. In severe cases with cardiac, ocular, or CNS involvement, corticosteroids may also be needed. Treatment may not be effective in ocular larva migrans; corticosteroid injections may reduce inflammation, and surgery may be needed for secondary damage.

Trichinosis

Mebendazole is used to treat trichinosis caused by Trichinella spiralis. Although some clinicians state that albendazole and mebendazole are equally effective for treating trichinosis, others consider mebendazole the drug of choice and albendazole the alternative, particularly during the tissue phase of the illness. Corticosteroids are usually recommended alongside the anthelmintic, especially when symptoms are severe. They help relieve symptoms of the inflammatory reaction and can be lifesaving when the heart or CNS is involved.

Trichuriasis

Mebendazole is used to treat trichuriasis caused by Trichuris trichiura (whipworm). Mebendazole is considered a drug of choice for treating trichuriasis.

Other Nematode Infections

Mebendazole used together with corticosteroids appeared to shorten the course of infection, though not the number of relapses, in several patients with eosinophilic meningitis caused by Angiostrongylus cantonensis. No medicine has been shown to be effective for treating this infection, and some patients have become worse when treated with albendazole, mebendazole, thiabendazole, or ivermectin. Mebendazole has been used in animals to treat angiostrongyliasis caused by A. costaricensis or A. malaysiensis.

Mebendazole is considered the drug of choice and albendazole is considered an alternative for treating capillariasis caused by Capillaria philippinensis. Although metronidazole generally is considered the drug of choice for infections caused by Dracunculus medinensis (guinea worm), since it has been shown to reduce inflammation and help remove the worm, mebendazole (400 to 800 mg daily for 6 days) has been reported to kill the worm directly. Mebendazole is used in the treatment of infections caused by Trichostrongylus. Pyrantel pamoate is considered the drug of choice and albendazole or mebendazole are alternatives for treating Trichostrongylus infections. Mebendazole is considered a drug of choice for treating trichuriasis caused by Trichuris trichiura (whipworm).

Cestode (Tapeworm) Infections

Mebendazole has been used to treat intestinal infections caused by the adult forms of certain tapeworms, including Hymenolepis nana (dwarf tapeworm), Taenia saginata (beef tapeworm), and T. solium (pork tapeworm). However, other anthelmintics, usually praziquantel, are recommended for treating intestinal infections caused by the adult forms of these cestodes.

Mebendazole has been effective in a limited number of patients for the treatment of hydatid disease caused by the larval form of Echinococcus granulosus (dog tapeworm). The manufacturers state that there is no evidence that mebendazole, even at high doses, is effective for treating hydatid disease. Surgery is considered the treatment of choice for hydatid disease when medically feasible, but an anthelmintic may be given around the time of surgery in patients having cysts removed to reduce the risk of intraoperative spread of daughter cysts. Mebendazole has been used in a very limited number of patients to treat alveolar hydatid disease caused by E. multilocularis. However, surgical removal of the larval mass is the recommended and only reliable treatment for these infections. Continuous treatment with albendazole or mebendazole has reportedly been associated with clinical improvement in cases that cannot be resected.

Giardiasis

Although metronidazole generally is the drug of choice for treating giardiasis caused by Giardia lamblia, mebendazole has been used in a limited number of adolescents and children.

Dosage and Administration

Mebendazole is used to treat a range of nematode (roundworm) infections, including trichuriasis (whipworm infection) caused by Trichuris trichiura, enterobiasis (pinworm infection) caused by Enterobius vermicularis, ascariasis (roundworm infection) caused by Ascaris lumbricoides, and hookworm infections caused by Ancylostoma duodenale, Necator americanus, or Ancylostoma caninum.

Administration

Mebendazole is taken by mouth. The tablets may be chewed, swallowed whole, or crushed and mixed with food. Special diets, fasting, or purgation before taking the medicine are not needed. Patients should be advised about hygiene measures to help reduce reinfection, such as wearing shoes, washing hands with soap and cleaning under fingernails often during the day, especially before eating and after using the toilet, and washing all fruit and vegetables thoroughly before eating them.

Dosage

Dosage is the same for adults and children. The manufacturer states that if the patient is not cured 3 weeks after mebendazole treatment, a second course of treatment is advised.

Nematode (Roundworm) Infections: Ascariasis

For the treatment of ascariasis caused by Ascaris lumbricoides, including mixed helminth infections, in adults and children, the usual dose of mebendazole is 100 mg twice daily for 3 consecutive days. Alternatively, some clinicians suggest that a single 500 mg dose of mebendazole can be used for treating ascariasis in adults and children.

Enterobiasis

For the treatment of enterobiasis caused by Enterobius vermicularis (pinworm) in adults and children, the usual dose of mebendazole is 100 mg as a single dose. In addition, some clinicians recommend that adults and children receive a second 100 mg dose of mebendazole 2 weeks later. The manufacturer states that if the patient is not cured within 3 weeks of the initial dose, a second dose should be given.

Filariasis

For the treatment of filariasis caused by Mansonella perstans, some clinicians recommend that adults and children receive mebendazole at a dose of 100 mg twice daily for 30 days. For the treatment of onchocerciasis (filariasis caused by Onchocerca volvulus) in adults, a mebendazole dose of 1 g twice daily for 28 days has been suggested.

Hookworm Infections

For the treatment of intestinal hookworm infections caused by Ancylostoma duodenale or Necator americanus, or for eosinophilic enterocolitis caused by Ancylostoma caninum (dog hookworm), the usual dose of mebendazole for adults and children is 100 mg twice daily for 3 consecutive days. Alternatively, some clinicians suggest that adults and children can receive a single 500 mg dose of mebendazole for treating hookworm infections caused by A. duodenale or N. americanus.

Toxocariasis (Visceral Larva Migrans)

For the treatment of toxocariasis (visceral larva migrans) caused by dog and cat roundworms, some clinicians recommend that adults and children receive mebendazole at a dose of 100 to 200 mg twice daily for 5 days. However, the optimum duration of treatment is not known, and some clinicians recommend continuing treatment for up to 20 days. A dose of 1 g 3 times daily (50 mg/kg/day) for 21 days reportedly cured at least one patient with this infection.

Trichinosis

The recommended dose of mebendazole for the treatment of trichinosis caused by Trichinella spiralis in adults and children is 200 to 400 mg 3 times daily for 3 days, followed by 400 to 500 mg 3 times daily for 10 days.

Trichuriasis

For the treatment of trichuriasis caused by Trichuris trichiura (whipworm), adults and children should receive mebendazole at a dose of 100 mg twice daily for 3 consecutive days. Alternatively, some clinicians suggest that adults and children can receive a single 500 mg dose of mebendazole.

Other Nematode Infections

For the treatment of capillariasis caused by Capillaria philippinensis, some clinicians recommend that adults and children receive mebendazole at a dose of 200 mg twice daily for 20 days. For the treatment of dracunculiasis caused by Dracunculus medinensis (guinea worm), a mebendazole dose of 400 to 800 mg daily for 6 days reportedly has killed the worm directly. For the treatment of infections caused by Trichostrongylus, adults and children should receive mebendazole at a dose of 100 mg twice daily for 3 consecutive days.

Cautions

Side effects

At the usual recommended doses (100 to 200 mg daily), mebendazole appears to cause few side effects. Side effects appear to be more common when higher doses, such as those used to treat extraintestinal infections including hydatid disease, are used, and in some cases may be related to the parasites being killed by the medicine. Temporary diarrhoea and abdominal pain have occurred occasionally during mebendazole treatment, but these usually have been associated with heavy infections and expulsion of the helminths. Nausea, vomiting, headache, tinnitus, numbness, and dizziness have also occasionally been reported during mebendazole treatment.

Fever has occurred in some patients, particularly in those receiving high-dose treatment for extraintestinal infections. Myelosuppression, seen as neutropenia (including agranulocytosis) and/or thrombocytopenia, has also been reported in patients receiving high-dose mebendazole treatment for extraintestinal infections (for example, 30 to 50 mg/kg/day). Although the myelosuppression was usually reversible after stopping the medicine, death has rarely occurred. Other side effects reported rarely in patients receiving mebendazole include alopecia, rash, pruritus, urticaria, angioedema, flushing, hiccups, cough, weakness, drowsiness, chills, hypotension, seizures, temporary abnormalities in liver function tests (for example, increased serum concentrations of aminotransferases, alkaline phosphatase, and/or bilirubin), increased BUN, decreased haemoglobin concentration and/or haematocrit, leukopenia, thrombocytopenia, eosinophilia, haematuria, and cylindruria. Migration of roundworms through the mouth and nose has also been reported.

Precautions and Contraindications

Mebendazole is contraindicated in patients who are hypersensitive to the medicine.

Paediatric Precautions

In British clinical practice, the safety of mebendazole in children younger than 2 years has not been established. Because of limited experience with mebendazole in children younger than 2 years, the medicine should be used in these children only when the potential benefits justify the possible risks.

Mutagenicity and Carcinogenicity

Animal and in vitro studies have not shown mebendazole to be mutagenic. No evidence of carcinogenesis was seen in rats and mice receiving mebendazole doses of up to 40 mg/kg/day for more than 2 years.

Pregnancy, Fertility, and Lactation

Mebendazole has been shown to be embryotoxic and teratogenic in rats when given as single oral doses as low as 10 mg/kg. Although there are no adequate and controlled studies to date in humans, the rate of spontaneous abortion and malformation did not exceed that in the general population in a limited number of women who inadvertently received the medicine during the first trimester of pregnancy; no teratogenic risk associated with mebendazole treatment was identified in 170 full-term deliveries. Mebendazole should be used during pregnancy, especially during the first trimester, only when the potential benefits justify the possible risks to the fetus. If the medicine is used during pregnancy, the patient should be informed of the potential risk to the fetus. Reproduction studies in male and female rats using mebendazole doses of up to 40 mg/kg for 60 days and 14 days before gestation, respectively, have not shown evidence of impaired fertility; however, slight maternal toxicity occurred. Since it is not known whether mebendazole passes into breast milk, the medicine should be used with caution in breastfeeding women.

Drug Interactions

Anticonvulsants

Limited data suggest that both carbamazepine and phenytoin may increase the metabolism of mebendazole, probably by inducing hepatic microsomal enzymes, which may lower plasma mebendazole concentrations. This interaction is unlikely to be clinically important in patients taking mebendazole for intestinal worm infections. However, carbamazepine or phenytoin may reduce the treatment response in patients taking the anthelmintic for extraintestinal infections (for example, hydatid disease). Until more data are available, alternative anticonvulsants such as valproic acid should be considered in patients taking mebendazole for extraintestinal infections.

Cimetidine

Preliminary evidence suggests that cimetidine inhibits mebendazole metabolism and may increase plasma concentrations of the drug.

Acute Toxicity

An overdose of mebendazole may cause GI symptoms lasting up to a few hours. If acute overdose occurs, vomiting and purging should be induced. Activated charcoal may be given.

Mechanism of Action

Although the exact mechanism of mebendazole's anthelmintic action has not been fully established, the drug appears to selectively and irreversibly inhibit the uptake of glucose and other low-molecular-weight nutrients in susceptible helminths. Inhibition of glucose uptake appears to deplete glycogen stores within the helminth. Mebendazole does not inhibit glucose uptake in mammals.

Mebendazole appears to cause degenerative changes in the intestine of nematodes and in the absorptive cells of cestodes. The drug's main anthelmintic effect appears to be degeneration of cytoplasmic microtubules within these intestinal and absorptive cells. Deterioration of the microtubules inhibits organelle movement and disrupts absorptive and secretory function. As a result of the excessive build-up of intracellular transport secretory granules, hydrolytic and proteolytic enzymes are released and cause cellular autolysis. This irreversible damage leads to death of the parasite.

Mebendazole has no effect on blood glucose concentrations in humans, and examination of the intestine and other organs of treated animals has shown an intact microtubular system and normal subcellular organelles. The presence of food in the digestive tract of the definitive host does not affect the action of the drug during treatment of intestinal helminth infections.

Spectrum: Mebendazole is active against certain nematodes (roundworms) that cause disease in humans, including Ancylostoma duodenale (hookworm), Angiostrongylus cantonensis, Ascaris lumbricoides (roundworm), Capillaria philippinensis (Philippine threadworm), Enterobius vermicularis (threadworm), Gnathostoma spinigerum, Necator americanus (hookworm), Strongyloides stercoralis (threadworm), Trichinella spiralis (pork worm), and Trichuris trichiura (whipworm). However, the drug's activity against S. stercoralis is variable and is usually less than its activity against other nematodes.

Mebendazole has been reported to be filaricidal against Mansonella perstans and Onchocerca volvulus. It has also been shown to be active against certain cestodes (tapeworms), including Hymenolepis nana (dwarf tapeworm), Taenia saginata (beef tapeworm), T. solium (pork tapeworm), and Echinococcus granulosus (hydatid cyst).

Pharmacokinetics

Absorption

Mebendazole appears to be minimally absorbed from the gastrointestinal tract after oral administration. Limited data suggest that about 2% to 10% of an oral dose is absorbed. Peak plasma concentrations of mebendazole occur about 0.5 to 7 hours after oral administration and vary widely between patients.

After oral administration of multiple doses of mebendazole (40 mg/kg daily) to 2 adults with hydatid cysts, mean peak plasma concentrations of about 0.08 micrograms/mL occurred at 0.5 to 2 hours. In another study, after a single oral dose of mebendazole 10 mg/kg in patients with hydatid cysts, peak plasma concentrations of about 0.02 to 0.04 micrograms/mL occurred at 1.5 to 7 hours. After oral administration of multiple doses of mebendazole (100 mg twice daily for 3 days) to several children, peak plasma mebendazole concentrations did not exceed 0.03 micrograms/mL, and peak plasma concentrations of the drug’s 2-amino metabolite, the main metabolite, did not exceed 0.09 micrograms/mL.

Distribution

Mebendazole is highly bound to plasma proteins. It is not known whether mebendazole passes into breast milk.

Elimination

The elimination half-life of mebendazole has been reported to be about 2.8-9 hours. Although the exact metabolic fate of mebendazole has not been fully determined, the drug is metabolised via decarboxylation to 2-amino-5(6)-benzimidazolyl phenylketone. This metabolite does not have anthelmintic activity. About 2-10% of an oral dose of mebendazole is excreted in the urine within 24-48 hours of administration, mainly as unchanged drug and the 2-amino metabolite. The metabolic fate and rate of excretion of unabsorbed mebendazole have not been determined.

Chemistry and Stability

Chemistry

Mebendazole is a synthetic benzimidazole-derivative anthelmintic. The drug is structurally related to albendazole and thiabendazole. Mebendazole is a white to slightly yellow powder and is practically insoluble in water and alcohol.

Stability

Commercially available mebendazole chewable tablets should be stored at 15-25°C in tightly closed containers and have a shelf life of 3 years from the date of manufacture.

Organs and Systems

Liver

All benzimidazoles can cause mild, reversible rises in transaminases, but even at high doses stopping treatment is justified in only a few patients.

Granulomatous hepatitis with eosinophilia has been attributed to mebendazole.

A 52-year-old man with ascariasis took two 3-day courses of mebendazole 100 mg twice daily, separated by a 2-week interval. Within 48 hours of the second course, he developed fever (39°C), diarrhoea, anorexia, and prostration. Ten days later, he was found to have tender hepatomegaly. Liver function tests were abnormal, with aspartate transaminase 466 IU/L and alanine transaminase 458 IU/L. Serum alkaline phosphatase and bilirubin were normal, and gamma-glutamyl transferase was mildly raised. The white blood cell count was 12.7 × 10⁹/L, with 18% eosinophils.

Coagulation was normal. Tests for hepatitis A, B, and C, cytomegalovirus, and Epstein-Barr virus were all negative. Serum ACE was not raised. Antimitochondrial antibodies were negative, but antinuclear antibodies and antibodies to smooth muscle were positive. Extensive tests to rule out other causes of granulomatous hepatitis were all negative. A liver biopsy showed multiple granulomata consisting of epithelioid cells, multinucleated giant cells, plasma cells, and lymphocytes.

There was slight fibrosis around the granulomata. There was no evidence of cholestasis. No helminth ova were found. Ziehl-Nielsen and periodic acid Schiff stains were both negative. After 2 days, the fever had settled without treatment and he felt better. Serum transaminases returned to normal over the next 10 weeks and the eosinophilia resolved.

Liver damage has been described after treatment with most benzimidazoles, but it is usually cholestatic. In this case, the liver damage was granulomatous. Liver damage after mebendazole at the low dose used in this case is rare, probably because of its poor absorption.

It is more common, although still rare, at the higher doses used in the treatment of human echinococcosis.

Urinary tract

Glomerulonephritis has been observed in five patients in Kenya.

Skin

Two cases of exfoliative dermatitis occurred among a total of 131 treated patients. In one case from India, a fixed drug eruption was attributed to the drug, and other types of rash have also been seen.

An outbreak of Stevens-Johnson syndrome has been reported in 52 Filipino overseas contract workers (aged 20-30 years, 50 women) working in China who used mebendazole for helminth prophylaxis. All took mebendazole at least once after the appearance of rash and fever. Three women eventually died, mainly due to septicaemia.

Side Effects

Mebendazole, a benzimidazole, is poorly absorbed from the gut, although it reliably enters cyst fluid, so it is most useful for treating intestinal infections and cyst-forming infestations. It is mainly an anthelmintic medicine and is effective against hookworm, ascariasis, enterobiasis, and trichuriasis. Mebendazole is effective against enteric Strongyloides but, because it is not absorbed, it is ineffective against tissue forms. However, it is also effective against Giardia lamblia, while Trichomonas vaginalis is susceptible in vitro. Mebendazole does not interfere with the normal intestinal flora.

Mebendazole has been assessed at a range of doses and treatment durations. The most usual dose is 100 mg twice daily for 3 days. Absorption is minimal, but there is considerable variation in plasma concentrations, and the half-life is 2-9 hours. Much higher doses, up to 60 mg/kg/day, have been used in inoperable cases of cystic echinococcosis, and unwanted effects are then more common.

Flubendazole is an analogue of mebendazole used in intestinal helminthiasis and hydatid disease. In trials of two-dose oral treatment for intestinal helminthiasis, reactions were mild and uncommon. They consisted of nausea, abdominal pain, dyspepsia, and sleepiness. Later field experience has not suggested that flubendazole differs appreciably from other drugs in the class in terms of side effects.

Comparative studies

Echinococcosis

The use of albendazole and mebendazole in patients with hydatid disease was evaluated in 448 patients with Echinococcus granulosus hydatid cysts. Patients received continuous oral treatment with albendazole 10 to 12 mg/kg daily for 3 to 6 months (323 patients) or mebendazole 50 mg/kg daily. At the end of treatment, 82% of cysts treated with albendazole and 56% of cysts treated with mebendazole showed degenerative changes. During long-term follow-up, 25% of these cysts relapsed, and in 78% of cases this occurred within 2 years. Further treatment with albendazole caused degenerative changes in more than 90% of the relapsed cysts, without more frequent or more severe adverse effects than those seen during the first treatment period.

Side effects during the first treatment period consisted of raised transaminases with albendazole (67 of 323 patients) and mebendazole (16 of 125 patients), and abdominal pain in 12% and 11% respectively. With both drugs, occasional patients experienced headache, abdominal distension, vertigo, urticaria, jaundice, thrombocytopenia, fever, or dyspepsia, but most of these are known manifestations of echinococcus infection. Six of 323 patients taking albendazole stopped treatment because of side effects, compared with eight of 125 patients taking mebendazole. Albendazole appears to be more effective than mebendazole in the treatment of hydatid cysts caused by E. granulosis, and the intensity and frequency of the usually mild side effects appear to be comparable with both drugs.

In 78 patients with hydatid disease, there was a low recurrence rate of hydatid disease (below 3%) after a postoperative prophylactic course of mebendazole 20 mg/kg/day in three divided doses for 3 months. The only side effect of mebendazole was excessive hair loss in two women. The unusually low recurrence rate of hydatid disease after treatment with mebendazole in this study was later questioned and attributed to meticulously careful surgical procedures, with avoidance of spillage of hydatid fluid and complete removal of parasitic components.

General adverse effects

With normal doses (100 mg twice daily for 3 days), very mild headache, dizziness, and nausea or diarrhoea are common. In principle, allergy can occur. Mild and reversible rises in transaminases can occur and should be monitored, but even at high doses stopping treatment is justified in only a few patients. Neutropenia has been noted and can be severe and persistent. High doses (up to 50-60 mg/kg) can also cause alopecia and cough. Mebendazole has been associated with extra-intestinal migration of Ascaris in heavily infected patients. Apart from the poor treatment response seen in about 25% of cases, drug toxicity, especially at high prolonged doses, has led to withdrawal in a small proportion of patients.

Side effects severe enough to lead to withdrawal have included worsening of pre-existing hyperlipidaemia (type IV), progressive uraemia, and a marked rise in liver enzymes. One individual developed a rash accompanied by a marked rise in serum transaminases, which recurred on later re-exposure. Experience in the treatment of Echinococcus multilocularis infection is similar. One patient with fatal agranulocytosis also had severe, probably unrelated, liver disease. Some 3-4% develop fever, which can be persistent and accompanied by respiratory symptoms and eosinophilia. Other side effects include pain over the site of the cyst, allergic reactions, alopecia, glomerulonephritis, and rashes.

Various authors have reported spontaneous rupture of hydatid cysts with mebendazole, and this is probably more common than in untreated individuals. Pleural and peritoneal cysts are more likely to rupture.

Evidence of teratogenicity in rats has not been accompanied by reports of harm in human pregnancy, but the World Health Organization (WHO) recommends avoiding it during the first trimester. It is not known whether mebendazole passes into breast milk. No side effects have been reported, but this has not been specifically studied.

Mebendazole: Organs and Systems

Susceptibility Factors

Age

In the UK, children under 2 years of age with helminth infections are currently excluded from treatment with mebendazole and other anthelmintic medicines based on the manufacturer's instructions. In a double-blind, randomised trial in Tanzania, 212 children under 2 years of age were given a total of 653 anthelmintic treatments (317 mebendazole 500 mg; 336 placebo). There were no significant differences in adverse events between the two groups. In light of the potential nutritional benefit of regular deworming in this age group, the policy of excluding children under 2 years of age from treatment should probably be reconsidered.

Storage

Store at room temperature 20-25°C (68-77°F). Keep in the original container, tightly closed, away from moisture and direct sunlight. Keep out of the reach of children.