Zyvox (Linezolid)

Zyvox
Indications:
infections

Dosages

Zyvox 600 mg

Quantity Price per tablet Total price
30 £5.48 £164.46
60 £5.22 £313.36

Payment & Delivery

Package Example

Your order is carefully packed and is dispatched within 24 hours. Here is what a typical package looks like.

Sized like a regular personal letter (approximately 24x11x0.7 cm), with no indication of what is inside.

Front View
Front View
Side View
Side View
Back View
Back View
Delivery Times
Delivery MethodEstimated delivery
Express Free for orders over £222.24Estimated delivery to the UK: 4-7 days
Standard Free for orders over £148.16Estimated delivery to the UK: 14-21 days
Payment Methods
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Brand Names

Also known as (by country):
CountryBrand Names
Austria
Zyvoxid
Bangladesh
Arlin
Canada
Zyvoxam
Czechia
Dilizolen
Egypt
Averozolid
France
Zyvoxid
Georgia
Anzolid
Germany
Zyvoxid
India
Linospan Linox Lizolid Lizomac Megazolid
Ireland
Zyvoxid
Italy
Zyvoxid
Kenya
Amizole 500
Netherlands
Dilizolen Grampolid Zyvoxid
Poland
Anozilad Dilizolen Zyvoxid
Portugal
Zyvoxid
Serbia
Anozilad
Slovakia
Dilizolen
Spain
Zyvoxid
Sweden
Zyvoxid
ManufacturerBrand Names
Cipla LimitedLinospan

Description

Note: Images in the description are provided for informational purposes and may differ from the actual appearance of the product. Please refer to the product name, strength, active ingredients, and pharmaceutical form.

Zyvox (linezolid) is an oxazolidinone antibiotic used to treat certain serious infections caused by susceptible Gram-positive bacteria. In UK clinical practice, it may be prescribed for appropriate infections when a clinician considers linezolid suitable.

Drug class

Linezolid belongs to the oxazolidinone class of antibiotics.

How it works

Linezolid blocks bacterial protein synthesis at an early stage by preventing formation of the 70S initiation complex.

What Zyvox tablets treat (and what they do not)

Illness / condition (A-Z) Zyvox tablets
Community-acquired pneumonia (CAP) +
Complicated skin and soft tissue infections +
Diabetic foot infection (without concomitant osteomyelitis) +
Gonorrhoea -
Gram-negative infections (e.g., E. coli, Pseudomonas) -
Hospital-acquired / nosocomial pneumonia (HAP) +
Osteomyelitis -
Pressure ulcers -
Uncomplicated skin and soft tissue infections +
Urinary tract infection (UTI) -
VRE (Enterococcus faecium) infection, including cases with concurrent bacteraemia +
Viral infections (flu/common cold) -
Yeast or other fungal infections -

Limitations of use (UK): Zyvox is not indicated for treating Gram-negative infections. If a Gram-negative pathogen is suspected or confirmed, appropriate treatment should be started.

Indications (US labelling)

Zyvox tablets are used for certain infections caused by susceptible Gram-positive bacteria, including pneumonia (nosocomial and community-acquired), skin and soft tissue infections (complicated and uncomplicated), and vancomycin-resistant Enterococcus faecium (VRE) infections, including cases with concurrent bacteraemia.

Tablet strength

Tablet: 600 mg (film-coated).

Can you split the tablet?

Zyvox 600 mg tablets are film-coated and are not supplied as scored tablets in the UK. For this reason, splitting or crushing them is generally not recommended unless a clinician specifically advises it.

Zyvox

Why is Zyvox expensive? Are there alternatives?

Cost can be influenced by brand pricing, manufacturing and supply chain factors, and market conditions. Depending on the infection and culture/susceptibility results, clinicians may choose alternatives. Generic linezolid tablets are available in the UK and may cost less than the branded product in some settings.

What medicines is it used with?

Zyvox may be used on its own for confirmed susceptible Gram-positive infections. If an infection is mixed or a Gram-negative pathogen is suspected, clinicians may prescribe Zyvox together with other antibiotics that cover Gram-negative organisms and, when needed, anaerobes. The exact combination depends on the site of infection, its severity, and local resistance patterns.

Drug interactions

Linezolid is a reversible, non-selective MAO inhibitor (MAOI). It can interact with adrenergic drugs, which may raise blood pressure, and serotonergic drugs, which may increase the risk of serotonin syndrome. Tell your UK clinician about all prescription medicines, medicines you buy without a prescription, and herbal products you use.

Contraindications

Contraindication What it means
Hypersensitivity to linezolid (or any component of the product) Do not use if you have a known serious allergy to linezolid or any of the ingredients in the product.
Use with MAO inhibitors (or within 2 weeks of stopping an MAOI) Do not use with MAOIs (e.g., phenelzine, isocarboxazid, selegiline) or within 2 weeks of stopping them because of the risk of interactions.

Tyramine (food interaction)

Because linezolid has MAOI activity, avoid consuming large amounts of tyramine-rich foods and drinks during treatment. Examples include mature cheeses, cured, aged or improperly stored meats, fermented foods (including some soya and yeast products), and certain alcoholic drinks such as some beers and red wine. Seek medical help if you develop a severe headache, flushing, or a marked rise in blood pressure.

Side effects and key precautions

Common side effects include diarrhoea, nausea, vomiting, and headache.

Important warnings and precautions include myelosuppression (including thrombocytopenia; full blood counts are commonly monitored weekly), peripheral and optic neuropathy (reported mainly with treatment lasting longer than 28 days), lactic acidosis, seizures, and C. difficile-associated diarrhoea. Report unusual bruising or bleeding, severe or persistent diarrhoea, or new visual symptoms promptly, including blurred vision or changes in visual acuity or colour vision.

Storage

Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F).

Reviewed by
Donna Brettler
BPharm, MPH - Pharmacologist and medical writer

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